Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.

نویسندگان

  • J M Chiller
  • B J Skidmore
  • D C Morrison
  • W O Weigle
چکیده

The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 70 7  شماره 

صفحات  -

تاریخ انتشار 1973